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EDEM1 Antibody - N-terminal region : Biotin (ARP47054_P050-Biotin)

Product Specifications

Gene Name

ER degradation enhancer, mannosidase alpha-like 1

Gene Aliases

EDEM

Gene ID

9695

Swiss Prot

Q92611

Accession Number

NP_055489

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human EDEM1

Target

EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner.

Partner Proteins

HLA-B; SQSTM1; UBC; MMS19; SSR1; ASGR1; DERL1; DNAJC10; DERL2; SEC61B; SEL1L; RHO; CANX; RCOM_2159910; ASGR2; ELAVL1; BZW1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

EDEM1 is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

74kDa

References & Citations

Zuber, C., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (11), 4407-4412

Shipping Conditions

Wet Ice

Product Datasheet

Anti-EDEM1 (ARP47054_P050-Biotin) antibody

Protein Length

657

NCBI Gene Symbol

EDEM1

NCBI GB Accession Number

EDEM1

Host or Source

Rabbit

Protein Name

ER degradation-enhancing alpha-mannosidase-like 1

Nucleotide Accession Number

NM_014674

Peptide Sequence

MAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAI

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