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NNT Antibody - N-terminal region : Biotin (ARP46892_P050-Biotin)

Selected Variant

ARP46892_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Nicotinamide nucleotide transhydrogenase

Gene Aliases

GCCD4

Gene ID

23530

Swiss Prot

Q13423

Accession Number

NP_036475

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human NNT

Target

NNT is an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD (H) and NADP (+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD (H) and NADP (+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Partner Proteins

MVP; UBC; TIMM10; PTCD1; FKBP8; POFUT1; UQCR11; ATP6V1F; PRPF3; LAMTOR3; SF1; THY1; ABCD3; NDUFS6; NDUFA9; SLC26A2; ATP5B; SLC25A6; SIRT7; MME; HNRNPA1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

114kDa

References & Citations

Mehrle, A., Nucleic Acids Res. 34 (DATABASE ISSUE), D415-D418 (2006)

Shipping Conditions

Wet Ice

Protein Length

1086

NCBI Gene Symbol

NNT

NCBI GB Accession Number

NNT

Host or Source

Rabbit

Protein Name

NAD (P) transhydrogenase, mitochondrial

Nucleotide Accession Number

NM_012343

Peptide Sequence

IVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEM

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