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RTN4 Antibody - middle region : Biotin (ARP46813_P050-Biotin)

Product Specifications

Gene Name

Reticulon 4

Gene Aliases

ASY, NSP, NOGO, RTN-X, NSP-CL, RTN4-A, RTN4-C, RTN4-B1, RTN4-B2, NI220/250, Nbla00271, Nbla10545

Gene ID

57142

Swiss Prot

Q7L7Q5

Accession Number

NP_008939

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human RTN4

Target

RTN4 belongs to the family of reticulons. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN4 is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.

Partner Proteins

HUWE1; SYT16; ZFYVE21; RTN4; SNX15; ARL6IP1; SNX1; UBC; RPA3; RPA2; RPA1; vpu; BAIAP2; LAMA4; ATF2; CLN8; TMEM65; S100A16; EPPK1; SNX12; ACAA2; SLC9A3R2; TJP1; HNRNPM; ILF3; IGFBP7; DDB1; SLC25A10; CIRBP; TERF1; POT1; RPS27; NR4A1; HLA-DPB1; RTN3; RTN4IP1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

22kDa

References & Citations

Hu, F. (2008) J. Neurosci. 28 (5), 1262-1269

Shipping Conditions

Wet Ice

Protein Length

199

NCBI Gene Symbol

RTN4

NCBI GB Accession Number

RTN4

Host or Source

Rabbit

Protein Name

Reticulon-4

Nucleotide Accession Number

NM_007008

Peptide Sequence

RAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV

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