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ZMPSTE24 Antibody - N-terminal region : Biotin (ARP46665_P050-Biotin)

Selected Variant

ARP46665_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Zinc metallopeptidase STE24 homolog (S. cerevisiae)

Gene Aliases

HGPS, PRO1, FACE1, STE24, FACE-1, Ste24p

Gene ID

10269

Swiss Prot

O75844

Accession Number

NP_005848

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ZMPSTE24

Target

ZMPSTE24 is a member of the peptidase M48A family. This protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in ZMPSTE24 gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.The protein encoded by this gene is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.

Partner Proteins

UBC; BAG3; KIAA2013; TMEM43; MRPL40; MRPS5; SYNJ2BP; ATP6V1H; HNRNPUL1; RAB10; VDAC1; UQCRFS1P1; S100A10; RAB5C; PTPN1; NDUFB7; MGST3; HNRNPF; GALNT2; DDOST; CD55; ELAVL1; MME

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 100%; Rat: 91%; Zebrafish: 90%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

55kDa

References & Citations

Moulson, C.L., (2005) J. Invest. Dermatol. 125 (5), 913-919

Shipping Conditions

Wet Ice

Protein Length

475

NCBI Gene Symbol

ZMPSTE24

NCBI GB Accession Number

ZMPSTE24

Host or Source

Rabbit

Protein Name

CAAX prenyl protease 1 homolog

Nucleotide Accession Number

NM_005857

Peptide Sequence

LYSETEGTLILLFGGIPYLWRLSGRFCGYAGFGPEYEITQSLVFLLLATL

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