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DGCR2 Antibody - N-terminal region : Biotin (ARP46575_P050-Biotin)

Product Specifications

Gene Name

DiGeorge syndrome critical region gene 2

Gene Aliases

IDD, LAN, DGS-C, SEZ-12

Gene ID

9993

Swiss Prot

P98153

Accession Number

NP_005128

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DGCR2

Target

Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.

Partner Proteins

HNRNPD; SMURF2; DDIT3

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

DGCR2 is strongly supported by BioGPS gene expression data to be expressed in SHSY5Y

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

61kDa

References & Citations

Olsen, J.V., (2006) Cell 127 (3), 635-648

Shipping Conditions

Wet Ice

Product Datasheet

Anti-DGCR2 (ARP46575_P050-Biotin) antibody

Protein Length

550

NCBI Gene Symbol

DGCR2

NCBI GB Accession Number

DGCR2

Host or Source

Rabbit

Protein Name

Integral membrane protein DGCR2/IDD

Nucleotide Accession Number

NM_005137

Peptide Sequence

MVPKADSGAFLLLFLLVLTVTEPLRPELRCNPGQFACRSGTIQCIPLPWQ

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