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ACSL3 Antibody - N-terminal region : FITC (ARP46453_P050-FITC)

Selected Variant

ARP46453_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Acyl-CoA synthetase long-chain family member 3

Gene Aliases

ACS3, FACL3, LACS3, LACS 3, PRO2194

Gene ID

2181

Swiss Prot

O95573

Accession Number

NP_004448

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ACSL3

Target

ACSL3 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.

Partner Proteins

UBC; SUMO2; STAU1; HIPK4; PPP6R1; PPP6R2; MAPK4; YES1; vpu; LYN; MTHFD1; ACSL4; APP; UBD; SIRT7; NDRG1; TMEM173; SPG20

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that ACSL3 is expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

80kDa

References & Citations

Yao, H. (2008) J. Biol. Chem. 283 (2), 849-854

Shipping Conditions

Wet Ice

Protein Length

720

NCBI Gene Symbol

ACSL3

NCBI GB Accession Number

ACSL3

Host or Source

Rabbit

Protein Name

Long-chain-fatty-acid--CoA ligase 3

Nucleotide Accession Number

NM_004457

Peptide Sequence

LDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKI

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