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CDT1 Antibody - C-terminal region : HRP (ARP46350_P050-HRP)

Selected Variant

ARP46350_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Chromatin licensing and DNA replication factor 1

Gene Aliases

DUP, RIS2

Gene ID

81620

Swiss Prot

Q9H211

Accession Number

NP_112190

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CDT1

Target

CDT1 cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It binds DNA in a sequence-, strand-, and conformation-independent manner and is a potential oncogene.

Partner Proteins

FBXO31; SKP1; RBX1; CUL1; DTL; PCNA; HECW2; CDK2; CDC6; CDC5L; ORC2; ORC1; GMNN; DGCR8; UBC; SKP2; CDK1; CCNB1; CCNA2; FOXO3; DDB1; COPS5; CUL4A; CUL4B; SMARCA5; MCM6; MAPK8; MAPK1; HDAC11; KAT7; CCNA1; DDB2; CDK4; CCNE1; TP63; TP73; EP300; KAT2B; CDT1; U

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 77%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Yeast: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

60kDa

References & Citations

Hu, J. (2006) J. Biol. Chem. 281 (7), 3753-3756

Shipping Conditions

Wet Ice

Protein Length

546

NCBI Gene Symbol

CDT1

NCBI GB Accession Number

CDT1

Host or Source

Rabbit

Protein Name

DNA replication factor Cdt1

Nucleotide Accession Number

NM_030928

Peptide Sequence

PATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQ

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