CDT1 Antibody - C-terminal region : Biotin (ARP46350_P050-Biotin)
Selected Variant
ARP46350_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Chromatin licensing and DNA replication factor 1
Gene Aliases
DUP, RIS2
Gene ID
81620
Swiss Prot
Q9H211
Accession Number
NP_112190
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Pig, Rabbit, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human CDT1
Target
CDT1 cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. It binds DNA in a sequence-, strand-, and conformation-independent manner and is a potential oncogene.
Partner Proteins
FBXO31; SKP1; RBX1; CUL1; DTL; PCNA; HECW2; CDK2; CDC6; CDC5L; ORC2; ORC1; GMNN; DGCR8; UBC; SKP2; CDK1; CCNB1; CCNA2; FOXO3; DDB1; COPS5; CUL4A; CUL4B; SMARCA5; MCM6; MAPK8; MAPK1; HDAC11; KAT7; CCNA1; DDB2; CDK4; CCNE1; TP63; TP73; EP300; KAT2B; CDT1; U
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 77%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Yeast: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
60kDa
References & Citations
Hu, J. (2006) J. Biol. Chem. 281 (7), 3753-3756
Shipping Conditions
Wet Ice
Protein Length
546
NCBI Gene Symbol
CDT1
NCBI GB Accession Number
CDT1
Host or Source
Rabbit
Protein Name
DNA replication factor Cdt1
Nucleotide Accession Number
NM_030928
Peptide Sequence
PATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQ
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