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DTNB Antibody - C-terminal region : FITC (ARP46310_P050-FITC)

Selected Variant

ARP46310_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Dystrobrevin, beta

Gene Aliases

MGC17163, MGC57126

Gene ID

1838

Swiss Prot

O60941

Accession Number

NP_149160

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DTNB

Target

DTNB is dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC) . The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin.This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC) . The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.

Partner Proteins

CEP55; ABI3; GGA1; NUP62; MTUS2; HMG20A; ABI2; PPFIA1; VCP; TRAF2; KRT31; DTNB; DMD; ZBTB9; TXLNA; KRT40; SPZ1; DTNBP1; USHBP1; NDEL1; CEP63; MLC1; UBC; PRTFDC1; SNTG2; SNTG1; CCDC85B; TSACC; KIF5A; BEGAIN; PPFIBP2; UTRN; SNTA1; KIF5B

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

64kDa

References & Citations

Nazarian, R., (2006) Biochem. J. 395 (3), 587-598

Shipping Conditions

Wet Ice

Protein Length

567

NCBI Gene Symbol

DTNB

NCBI GB Accession Number

DTNB

Host or Source

Rabbit

Protein Name

Dystrobrevin beta

Nucleotide Accession Number

NM_033148

Peptide Sequence

ASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEEL

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