DTL Antibody - N-terminal region : Biotin (ARP46248_P050-Biotin)
Product Specifications
Gene Name
Denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Gene Aliases
CDT2, RAMP, DCAF2, L2DTL
Gene ID
51514
Swiss Prot
Q9NZJ0
Accession Number
NP_057532
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DTL
Target
DTL is required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. It seems to be necessary to ensure proper cell cycle regulation of DNA replication. DTL may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. It also may play a role in cell proliferation of NT2 embryonal carcinoma cells.
Partner Proteins
FBXO11; YWHAQ; CUL4A; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; UBE2D1; UBC; PCNA; SFN; DDB1; FBXO18; CDT1; CUL4B; TDG; LYN; SHPRH; RAD18; COPS5; HLTF; CHEK1; CFTR; CDKN1A; DDA1; COPS4; COPS6; TOB1; COPS3; TUBG1; ATR; AURKB; TP53; MDM2; MSH2; MSH6; KAT2A; Dtl; S
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
DTL is supported by BioGPS gene expression data to be expressed in 721_B
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
79kDa
References & Citations
Sansam, C.L., (2006) Genes Dev. 20 (22), 3117-3129
Shipping Conditions
Wet Ice
Protein Length
730
NCBI Gene Symbol
DTL
NCBI GB Accession Number
DTL
Host or Source
Rabbit
Protein Name
Denticleless protein homolog
Nucleotide Accession Number
NM_016448
Peptide Sequence
VNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLV
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