PSME3 Antibody - N-terminal region : Biotin (ARP46142_P050-Biotin)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME3 is the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring.

SPG7; PRKAB2; PFDN5; BBS2; TNFAIP8L1; EAF1; ZCCHC10; PRR13; TXN2; FBXO7; DIP2A; PSME3; HUWE1; TUBGCP3; SIRT1; CREBBP; PSMD14; SHFM1; GTPBP4; MDM2; ADARB2; C1QBP; PARK2; CLK3; CLK2; YWHAQ; TBXA2R; BAG3; NPM1; ITGA4; CBX2; vpr; vif; HCVgp1; CBX4; VCAM1; UBC

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.