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LMNB1 Antibody - middle region: Biotin (ARP46137_P050-Biotin)

Product Specifications

Gene Name

Lamin B1

Gene Aliases

LMN, ADLD, LMN2, LMNB, MCPH26

Gene ID

4001

Swiss Prot

P20700

Accession Number

NP_005564

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human LMNB1

Target

LAMNB1 encodes for one of the two B type proteins of the nuclear lamina, B1. The Vertebrate lamins consist of two types, A and B. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

POU2F1; SPRTN; UBC; SUMO2; SUMO3; MDM2; EED; ACTR10; NCAPH; ZZEF1; DCTN3; DCTN2; ACTR1A; ACTR1B; PARK2; HECW2; YWHAQ; ADRB2; LMNA; MELK; URB2; FN1; ATF4; SERPINA3; ABCG8; MBIP; GIT2; WHSC1; VCAM1; ITGA4; PRKCB; CDK1; MAGT1; HP1BP3; NCSTN; HNRNPM; EIF6; IL

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

LMNB1 is supported by BioGPS gene expression data to be expressed in SKMEL2

Concentration

0.5 mg/mL

Homology

Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 91%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

66kDa

Shipping Conditions

Wet Ice

Protein Length

586

NCBI Gene Symbol

LMNB1

Protein Name

Lamin-B1

Nucleotide Accession Number

NM_005573

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