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SMC4 Antibody - middle region : HRP (ARP46131_P050-HRP)

Product Specifications

Gene Name

Structural maintenance of chromosomes 4

Gene Aliases

CAPC, CAP-C, SMC-4, SMC4L1

Gene ID

10051

Swiss Prot

Q9NTJ3

Accession Number

NP_001002800

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SMC4

Target

SMC4 is the central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Partner Proteins

UBC; SUMO2; LGR4; RPA3; RPA2; RPA1; RNF2; NCAPH; SMC2; SSSCA1; NCAPD2; TBC1D4; PLEC; AP3S1; CDK9; NCAPG; CCAR2; RABL6; TOPBP1; FBXO6; UBD; HDAC11; MYC; Nfe2l2; NEDD8; CDK2; SIRT7; NCAPH2; NCAPD3; RAD21; TRAF3IP1; SUMO1; HDAC1; tat; DNMT3B

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that SMC4 is expressed in MCF7

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

147kDa

References & Citations

Ham, M.F., (2007) Cancer Sci. 98 (7), 1041-1047

Shipping Conditions

Wet Ice

Protein Length

1288

NCBI Gene Symbol

SMC4

NCBI GB Accession Number

SMC4

Host or Source

Rabbit

Protein Name

Structural maintenance of chromosomes protein 4

Nucleotide Accession Number

NM_001002800

Peptide Sequence

EARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRK

Frequently Asked Questions

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