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SMC4 Antibody - N-terminal region : Biotin (ARP46130_P050-Biotin)

Product Specifications

Gene Name

Structural maintenance of chromosomes 4

Gene Aliases

CAPC, CAP-C, SMC-4, SMC4L1

Gene ID

10051

Swiss Prot

Q9NTJ3

Accession Number

NP_001002800

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SMC4

Target

SMC4 is the central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Partner Proteins

UBC; SUMO2; LGR4; RPA3; RPA2; RPA1; RNF2; NCAPH; SMC2; SSSCA1; NCAPD2; TBC1D4; PLEC; AP3S1; CDK9; NCAPG; CCAR2; RABL6; TOPBP1; FBXO6; UBD; HDAC11; MYC; Nfe2l2; NEDD8; CDK2; SIRT7; NCAPH2; NCAPD3; RAD21; TRAF3IP1; SUMO1; HDAC1; tat; DNMT3B

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

SMC4 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 100%; Pig: 86%; Rabbit: 93%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

147kDa

References & Citations

Ham, M.F., (2007) Cancer Sci. 98 (7), 1041-1047

Shipping Conditions

Wet Ice

Protein Length

1288

NCBI Gene Symbol

SMC4

NCBI GB Accession Number

SMC4

Host or Source

Rabbit

Protein Name

Structural maintenance of chromosomes protein 4

Nucleotide Accession Number

NM_001002800

Peptide Sequence

SGRTESPATAAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMIT

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