PSMB8 Antibody - N-terminal region : FITC (ARP46099_P050-FITC)

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex) . Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.

IKBKG; PSMB7; PSMB6; PSMB5; PSMB4; PSMB2; PSMB1; PSMA6; PSMA5; PSMA4; PSMA3; PSMA1; HNRNPM; EIF4G1; GCN1L1; CCT2; RPP38; DHX38; PSMA2; PSMA7; PSMA8; USP9X; PSMD8; PSMC5; PSMC4; PSMC3; PSMC2; PSMC1; PSMB3; UBC; PSME2; PSME1; HCVgp1; POMP; TAP2; TAP1; PSMB1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.