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PPAT Antibody - N-terminal region : FITC (ARP46079_P050-FITC)

Selected Variant

ARP46079_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Phosphoribosyl pyrophosphate amidotransferase

Gene Aliases

GPAT, PRAT, ATASE

Gene ID

5471

Swiss Prot

Q06203

Accession Number

NP_002694

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PPAT

Target

PPAT is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. Its gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4.The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4.

Partner Proteins

FAM96B; CIAO1; FAM114A1; PARVA; CARM1; RANBP3; TROVE2; RSU1; MEA1; ILK; HSPA4; GART; CARS; MMS19; EPT1; ATXN1; SMURF1; MCM3; UBC

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

PPAT is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Rabbit: 93%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

56kDa

References & Citations

Bera, A.K., (1999) J. Biol. Chem. 274 (51), 36498-36504

Shipping Conditions

Wet Ice

Protein Length

517

NCBI Gene Symbol

PPAT

NCBI GB Accession Number

PPAT

Host or Source

Rabbit

Protein Name

Amidophosphoribosyltransferase

Nucleotide Accession Number

NM_002703

Peptide Sequence

VTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKC

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