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HSPA4 Antibody - middle region : HRP (ARP46074_P050-HRP)

Product Specifications

Gene Name

Heat shock 70kDa protein 4

Gene Aliases

RY, APG-2, HSPH2, hsp70, hsp70RY, HEL-S-5a, HS24/P52

Gene ID

3308

Swiss Prot

P34932

Accession Number

NP_002145

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HSPA4

Target

HSPA4 (Hsp70) belongs to the heat shock protein 70 family. It was isolated as a putative Rictor interacting protein and interaction with membranes acts as a platform for its release into the extracellular environment during its recovery from stress. Hsp70 gene expression in Rheumatoid Arthitis-affected synovial tissue is followed by Hsp70 cell surface expression on fibroblast-like synovial cells growing from RA synovial tissue. Serum Hsp70 levels were increased in Systemic sclerosis patients, and associated with pulmonary fibrosis, skin sclerosis, renal vascular damage, oxidative stress, and inflammation.

Partner Proteins

TP53; CDC25C; CDK1; AGTRAP; ERLIN2; HUWE1; Slc12a3; APPBP2; PSMD10; UBC; SUMO2; SUMO3; SIK2; MAP3K11; VHL; UIMC1; PRKCG; PRKCD; STUB1; HIF1A; ENDOG; HSPA8; TRIM5; USP19; PA2G4; WWOX; NDRG1; GZMA; GART; CRMP1; CDKN2A; CARS; PPM1G; PPAT; KARS; FAM114A1; HSP

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

HSPA4 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

94kDa

References & Citations

Kim, H.E., (2008) Mol. Cell 30 (2), 239-247

Shipping Conditions

Wet Ice

Product Datasheet

Anti-HSPA4 (ARP46074_P050-HRP) antibody

Protein Length

840

NCBI Gene Symbol

HSPA4

NCBI GB Accession Number

HSPA4

Host or Source

Rabbit

Protein Name

Heat shock 70 kDa protein 4

Nucleotide Accession Number

NM_002154

Peptide Sequence

PIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTK

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