HSPA4 Antibody - N-terminal region : Biotin (ARP46073_P050-Biotin)
Product Specifications
Gene Name
Heat shock 70kDa protein 4
Gene Aliases
RY, APG-2, HSPH2, hsp70, hsp70RY, HEL-S-5a, HS24/P52
Gene ID
3308
Swiss Prot
P34932
Accession Number
NP_002145
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human HSPA4
Target
HSPA4 (Hsp70) belongs to the heat shock protein 70 family. It was isolated as a putative Rictor interacting protein and interaction with membranes acts as a platform for its release into the extracellular environment during its recovery from stress. Hsp70 gene expression in Rheumatoid Arthitis-affected synovial tissue is followed by Hsp70 cell surface expression on fibroblast-like synovial cells growing from RA synovial tissue. Serum Hsp70 levels were increased in Systemic sclerosis patients, and associated with pulmonary fibrosis, skin sclerosis, renal vascular damage, oxidative stress, and inflammation.
Partner Proteins
TP53; CDC25C; CDK1; AGTRAP; ERLIN2; HUWE1; Slc12a3; APPBP2; PSMD10; UBC; SUMO2; SUMO3; SIK2; MAP3K11; VHL; UIMC1; PRKCG; PRKCD; STUB1; HIF1A; ENDOG; HSPA8; TRIM5; USP19; PA2G4; WWOX; NDRG1; GZMA; GART; CRMP1; CDKN2A; CARS; PPM1G; PPAT; KARS; FAM114A1; HSP
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
94kDa
References & Citations
Kim, H.E., (2008) Mol. Cell 30 (2), 239-247
Shipping Conditions
Wet Ice
Protein Length
840
NCBI Gene Symbol
HSPA4
NCBI GB Accession Number
HSPA4
Host or Source
Rabbit
Protein Name
Heat shock 70 kDa protein 4
Nucleotide Accession Number
NM_002154
Peptide Sequence
PACISFGPKNRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKS
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