EIF2S3 Antibody - N-terminal region : Biotin (ARP46057_P050-Biotin)
Product Specifications
Gene Name
Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Gene Aliases
EIF2, EIF2G, MEHMO, MRXSBRK, eIF-2gA, EIF2gamma
Gene ID
1968
Swiss Prot
P41091
Accession Number
NP_001406
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human EIF2S3
Target
EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Partner Proteins
UBC; RNF2; rev; CCAR2; PLD3; EEF1E1; AIMP1; AIP; IQGAP1; RARS; QARS; IMPDH2; DNAJA1; EIF2S1; MAPK6; TARDBP; FN1; UBD; GRK5; CAND1; CDK2; SUMO1; ELAVL1; SUMO2; NDRG1; RAD21; HDGF; DCC; METAP2; EIF1B; CASP4; H3F3A; CTCF
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
51kDa
References & Citations
Tu, L.C., (2007) Mol. Cell Proteomics 6 (4), 575-588
Shipping Conditions
Wet Ice
Protein Length
472
NCBI Gene Symbol
EIF2S3
NCBI GB Accession Number
EIF2S3
Host or Source
Rabbit
Protein Name
Eukaryotic translation initiation factor 2 subunit 3
Nucleotide Accession Number
NM_001415
Peptide Sequence
AGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVA
Subunit
3
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