CENPA Antibody - middle region : Biotin (ARP46041_P050-Biotin)

Product Specifications

Gene Name

Centromere protein A

Gene Aliases

CenH3, CENP-A

Gene ID

1058

Swiss Prot

P49450

Accession Number

NP_001800

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CENPA

Target

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA is a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle.Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Partner Proteins

HIST1H4A; HIST1H2AB; H3F3A; HIST1H2BB; DIAPH3; DIAPH1; NPM1; HIST1H1A; H2AFZ; H2AFX; CENPC; CENPB; HIST3H2BB; HIST4H4; CENPT; CENPU; CENPM; CENPH; CENPN; HJURP; SUPT16H; H2AFY; AURKB; HIST1H3E; HIST2H2AC; SSRP1; RUVBL1; XRCC5; PRKDC; HNRNPU; EIF4A1; DDX5

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

CENPA is strongly supported by BioGPS gene expression data to be expressed in 721_B, HeLa

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 77%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.