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KYNU Antibody - C-terminal region : HRP (ARP46037_P050-HRP)

Product Specifications

Gene Name

Kynureninase

Gene Aliases

KYNUU, VCRL2

Gene ID

8942

Swiss Prot

Q16719

Accession Number

NP_003928

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human KYNU

Target

Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway.Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene.Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Two transcript variants encoding different isoforms have been found for this gene.

Partner Proteins

LDHAL6B; BCCIP; CNDP2; NAGK; CHORDC1; C11orf58; NDRG1; GDA; SMS; RPS6KA1; PEPD; MVD; LDHA; GSR; GNS; CSE1L; ADSS; LYN; UBC; PALM2; SMEK2; SSU72; SIRT1; NUP210; SEC23IP; COIL; TPM3; SMARCD2; SGTA; PPM1G; ASNS

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

KYNU is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 86%; Yeast: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

52kDa

References & Citations

Suzuki, Y., Gene 200 (1-2), 149-156 (1997)

Shipping Conditions

Wet Ice

Product Datasheet

Anti-KYNU (ARP46037_P050-HRP) antibody

Protein Length

465

NCBI Gene Symbol

KYNU

NCBI GB Accession Number

KYNU

Host or Source

Rabbit

Protein Name

Kynureninase

Nucleotide Accession Number

NM_003937

Peptide Sequence

LAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP

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