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RRM2B Antibody - middle region : FITC (ARP46032_P050-FITC)

Selected Variant

ARP46032_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Ribonucleotide reductase M2

Gene Aliases

P53R2, MTDPS8A, MTDPS8B

Gene ID

50484

Swiss Prot

Q7LG56-2

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of Human RRM2B

Target

This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.

Partner Proteins

RRM2B; ORC4; UBC; AICDA; RRM1; TP53; RRM2; MDM2; ATM; ZBTB17; MYC

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%; Yeast: 93%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

32kDa

Shipping Conditions

Wet Ice

Protein Length

299

NCBI Gene Symbol

RRM2B

NCBI GB Accession Number

RRM2B

Host or Source

Rabbit

Protein Name

Ribonucleoside-diphosphate reductase subunit M2 B

Peptide Sequence

VHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKST

Price

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