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RRM2 Antibody - N-terminal region : HRP (ARP46031_P050-HRP)

Selected Variant

ARP46031_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Ribonucleotide reductase M2

Gene Aliases

R2, RR2, RR2M, C2orf48

Gene ID

6241

Swiss Prot

P31350

Accession Number

NP_001025

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RRM2

Target

RRM2 provides the precursors necessary for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 inhibits Wnt signaling.Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, proteins M1 and M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

DNM1L; UBC; gag-pol; RBMX; PCMT1; NONO; UBD; SKP2; NR1H4; RRM1; CCNF; ELAVL1; KAT5; RRM2B; CDH1; TP53; CDK1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

45kDa

References & Citations

Souglakos, J., (2008) Br. J. Cancer 98 (10), 1710-1715

Shipping Conditions

Wet Ice

Protein Length

389

NCBI Gene Symbol

RRM2

NCBI GB Accession Number

RRM2

Host or Source

Rabbit

Protein Name

Ribonucleoside-diphosphate reductase subunit M2

Nucleotide Accession Number

NM_001034

Peptide Sequence

PALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFP

Subunit

M2

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