RRM2 Antibody - N-terminal region : Biotin (ARP46031_P050-Biotin)
Product Specifications
Gene Name
Ribonucleotide reductase M2
Gene Aliases
R2, RR2, RR2M, C2orf48
Gene ID
6241
Swiss Prot
P31350
Accession Number
NP_001025
Host
Rabbit
Reactivity
Human, Rat, Cow, Dog, Guinea Pig, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human RRM2
Target
RRM2 provides the precursors necessary for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RRM2 inhibits Wnt signaling.Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, proteins M1 and M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Partner Proteins
DNM1L; UBC; gag-pol; RBMX; PCMT1; NONO; UBD; SKP2; NR1H4; RRM1; CCNF; ELAVL1; KAT5; RRM2B; CDH1; TP53; CDK1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
45kDa
References & Citations
Souglakos, J., (2008) Br. J. Cancer 98 (10), 1710-1715
Shipping Conditions
Wet Ice
Protein Length
389
NCBI Gene Symbol
RRM2
NCBI GB Accession Number
RRM2
Host or Source
Rabbit
Protein Name
Ribonucleoside-diphosphate reductase subunit M2
Nucleotide Accession Number
NM_001034
Peptide Sequence
PALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFP
Subunit
M2
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