SOD1 Antibody - N-terminal region: Biotin (ARP45752_T100-Biotin)
Product Specifications
Gene Name
Superoxide dismutase 1, soluble
Gene Aliases
ALS, SOD, ALS1, IPOA, STAHP, hSod1, HEL-S-44, homodimer
Gene ID
6647
Swiss Prot
P00441
Accession Number
NP_000445
Host
Rabbit
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SOD1
Target
SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in its gene have been implicated as causes of familial amyotrophic lateral sclerosis.The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Partner Proteins
SOD1; CRYAB; UBC; SMAD2; HDAC6; GSH1; OPTN; PRDX5; AHCYL1; TIAL1; PRDX2; SPTBN1; SOD2; PPP2CA; PPIA; PLS3; PRDX1; NME2; NME1; Hspa4l; Hspa4; Hspa2; Hspa1b; Hsph1; Dnaja1; Hspa8; Hspa5; Ccs; UBE3A; COMMD1; Stub1; SUMO4; DYNLT1; AMFR; MARCH5; RNF19A; PSMD4
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Sample Type
SOD1 is supported by BioGPS gene expression data to be expressed in Jurkat
Concentration
0.5 mg/mL
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
16kDa
Shipping Conditions
Wet Ice
Protein Length
154
NCBI Gene Symbol
SOD1
Protein Name
Superoxide dismutase [Cu-Zn]
Nucleotide Accession Number
NM_000454
Curated Selection
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