NR1H4 Antibody - middle region : Biotin (ARP45626_P050-Biotin)

Product Specifications

Gene Name

Nuclear receptor subfamily 1, group H, member 4

Gene Aliases

BAR, FXR, HRR1, HRR-1, PFIC5, RIP14

Gene ID

9971

Swiss Prot

B6ZGS9

Accession Number

NP_005114

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NR1H4

Target

NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d

Partner Proteins

SMARCD3; HDAC6; SUMO1; NCOR2; ESR1; RRM2; GPS2; RXRG; GAPDH; RXRA; EP300; SIRT1; SRC; NCOA6; CARM1; HIST1H4A; HIST1H3A; PRMT1; NCOR1; XRCC5; PRKDC; XRCC6; NCOA1; CASP8; SMARCD1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.