NR3C2 Antibody - middle region: Biotin (ARP45599_T100-Biotin)
Product Specifications
Gene Name
Nuclear receptor subfamily 3, group C, member 2
Gene Aliases
MR, MCR, MLR, NR3C2VIT
Gene ID
4306
Swiss Prot
P08235
Accession Number
NP_000892
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human NR3C2
Target
NR3C2 is a receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. It binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Partner Proteins
RABAC1; RXRA; HSP90AA1; ACSL1; UBC; SRC; PPP5C; PPID; FKBP5; FKBP4; STUB1; AIP; TRIM24; NRIP1; DNAJC7; CAND1; SUMO1; UBE2I; EIF3I; PROX1; PIAS1; PIAS3; HSPA4; PTGES3; AR; NR3C1; ACTA1; ACTG1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
IHC, WB
Sample Type
NR3C2 is supported by BioGPS gene expression data to be expressed in A172
Concentration
0.5 mg/mL
Homology
Cow: 83%; Guinea Pig: 75%; Horse: 86%; Human: 100%; Mouse: 92%; Pig: 93%; Rabbit: 100%; Rat: 92%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
107kDa
Shipping Conditions
Wet Ice
Protein Length
984
NCBI Gene Symbol
NR3C2
Protein Name
Mineralocorticoid receptor
Nucleotide Accession Number
NM_000901
Curated Selection
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