LBR Antibody - middle region : Biotin (ARP45263_P050-Biotin)

Product Specifications

Gene Name

Lamin B receptor

Gene Aliases

PHA, C14SR, LMN2R, PHASK, TDRD18, DHCR14B

Gene ID

3930

Swiss Prot

Q14739

Accession Number

NP_002287

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human LBR

Target

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Partner Proteins

UBC; EED; CLK3; HIPK4; LMNA; HNRNPR; EIF4A3; ILF2; HNRNPU; DHX15; DHX9; KCND3; PPP1CC; PPP1CB; PPP1CA; TCF3; ARRB2; SUMO2; HIST2H4A; HIST1H3A; tat; CBX5; SRPK1; FNBP4; AKAP8L; YWHAG; CBX3; LBR; PRM1; LMNB1; MECP2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

LBR is supported by BioGPS gene expression data to be expressed in RPMI 8226

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 100%; Yeast: 77%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.