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GZMK Antibody - middle region : FITC (ARP45220_P050-FITC)

Product Specifications

Gene Name

Granzyme K (granzyme 3; tryptase II)

Gene Aliases

TRYP2

Gene ID

3003

Swiss Prot

P49863

Accession Number

NP_002095

Host

Rabbit

Reactivity

Human, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human GZMK

Target

GZMK is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

SET; HMGB2; APEX1; PNKP; LIG4; HNRNPK; GOLGA2; ACTG1; TUBB3; NPLOC4; VCP; UFD1L

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Human: 100%; Pig: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

26kDa

References & Citations

Rucevic, M., (2007) Shock 27 (5), 488-493

Shipping Conditions

Wet Ice

Protein Length

264

NCBI Gene Symbol

GZMK

NCBI GB Accession Number

GZMK

Host or Source

Rabbit

Protein Name

Granzyme K

Nucleotide Accession Number

NM_002104

Peptide Sequence

LRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQSYYNGDPF

Frequently Asked Questions

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