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HBEGF Antibody - N-terminal region: HRP (ARP45201_P050-HRP)

Product Specifications

Gene Name

Heparin-binding EGF-like growth factor

Gene Aliases

DTR, DTS, DTSF, HEGFL

Gene ID

1839

Swiss Prot

Q99075

Accession Number

NP_001936

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human HBEGF

Target

HBEGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It is required for normal cardiac valve formation and normal heart function. HBEGF promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It also acts as a diphtheria toxin receptor.

Partner Proteins

Bag1; BCL6; ZBTB16; CD82; NRD1; LTBP3; ERBB4; MMP7; CD9; FBLN1; EGFR; HBEGF; CD44

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that HBEGF is expressed in PANC1

Concentration

0.5 mg/mL

Homology

Cow: 100%; Dog: 86%; Guinea Pig: 79%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

22kDa

Shipping Conditions

Wet Ice

Protein Length

208

NCBI Gene Symbol

HBEGF

Protein Name

Proheparin-binding EGF-like growth factor

Nucleotide Accession Number

NM_001945

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