ACVR2B Antibody - C-terminal region : FITC (ARP45043_P050-FITC)

Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

GDF2; BMP10; INHBA; PEG10; ERBB2IP; HSP90AA1; SMAD7; SMAD6; SMAD2; IGSF1; SYNJ2BP; SNX6; SNX2; TGFBRAP1; GDF11; MSTN; ACVR1B; SNX1; INHBC; GDF5; INHBB; BMP7; BMP2; ENG; BMP6

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.