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SPPL2B Antibody - N-terminal region : FITC (ARP44989_P050-FITC)

Selected Variant

ARP44989_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Signal peptide peptidase like 2B

Gene Aliases

IMP4, PSH4, PSL1, IMP-4

Gene ID

56928

Swiss Prot

Q8TCT7-4

Accession Number

NP_001070706

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SPPL2B

Target

SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

SPPL2B is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

56kDa

Shipping Conditions

Wet Ice

Protein Length

511

NCBI Gene Symbol

SPPL2B

NCBI GB Accession Number

SPPL2B

Host or Source

Rabbit

Protein Name

Signal peptide peptidase-like 2B

Nucleotide Accession Number

NM_001077238

Peptide Sequence

VARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVAL

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