SPPL2B Antibody - N-terminal region : Biotin (ARP44988_P050-Biotin)
Selected Variant
ARP44988_P050-Biotin
Size: 100 µL
Product Specifications
Gene Name
Signal peptide peptidase like 2B
Gene Aliases
IMP4, PSH4, PSL1, IMP-4
Gene ID
56928
Swiss Prot
Q8TCT7-3
Accession Number
NP_694533
Host
Rabbit
Reactivity
Human, Rat, Cow, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPPL2B
Target
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 79%; Horse: 86%; Human: 100%; Pig: 79%; Rat: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
33kDa
Shipping Conditions
Wet Ice
Protein Length
307
NCBI Gene Symbol
SPPL2B
NCBI GB Accession Number
SPPL2B
Host or Source
Rabbit
Protein Name
Signal peptide peptidase-like 2B
Nucleotide Accession Number
NM_152988
Peptide Sequence
AHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYE
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