ITM2C Antibody - middle region: FITC (ARP44631_P050-FITC)
Product Specifications
Gene Name
Integral membrane protein 2C
Gene Aliases
E25, BRI3, E25C, ITM3, BRICD2C
Gene ID
81618
Swiss Prot
Q9NQX7
Accession Number
NP_112188
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Target
ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Partner Proteins
UBC; Dlg4; RYK; BACE1; RNF7; STT3A; MTNR1B; FURIN
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 91%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
30kDa
Shipping Conditions
Wet Ice
Protein Length
267
NCBI Gene Symbol
ITM2C
Protein Name
Integral membrane protein 2C
Nucleotide Accession Number
NM_030926
Curated Selection
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