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MTUS1 Antibody - middle region : Biotin (ARP44419_P050-Biotin)

Product Specifications

Gene Name

Microtubule associated tumor suppressor 1

Gene Aliases

ATBP, ATIP, ICIS, MP44, ATIP3, MTSG1

Gene ID

57509

Swiss Prot

Q9ULD2

Accession Number

NP_001001924

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human MTUS1

Target

MTUS1 contains a C-terminal domain and is able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. One of the isoforms has been shown to be a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other isoforms may be nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.

Partner Proteins

UBC; MMS19; ORC4; Ptpn6; MTUS1; AGTR2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

MTUS1 is strongly supported by BioGPS gene expression data to be expressed in HeLa, HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

141kDa

References & Citations

Uhl, G.R., (2008) Arch. Gen. Psychiatry 65 (6), 683-693

Shipping Conditions

Wet Ice

Protein Length

1270

NCBI Gene Symbol

MTUS1

NCBI GB Accession Number

MTUS1

Host or Source

Rabbit

Protein Name

Microtubule-associated tumor suppressor 1

Nucleotide Accession Number

NM_001001924

Peptide Sequence

KRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR

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