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LDLR Antibody - C-terminal region : FITC (ARP44305_P050-FITC)

Selected Variant

ARP44305_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Low density lipoprotein receptor

Gene Aliases

FH, FHC, FHCL1, LDLCQ2

Gene ID

3949

Swiss Prot

P01130-2

Accession Number

NP_001182732

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human LDLR

Target

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Partner Proteins

PCSK9; UBC; env; MAP4; PDIA3; CREBBP; PDIA4; HSP90B1; HSPA5; CANX; MYLIP; AP1M2; LDLR; SNX17; LDLRAP1; DAB1; PF4; APOE; APOB; LRPAP1; DAB2; CD36

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

75kDa

Shipping Conditions

Wet Ice

Protein Length

682

NCBI Gene Symbol

LDLR

NCBI GB Accession Number

LDLR

Host or Source

Rabbit

Protein Name

Low-density lipoprotein receptor

Nucleotide Accession Number

NM_001195803

Peptide Sequence

VDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEA

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