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NEU1 Antibody - middle region : FITC (ARP44286_T100-FITC)

Selected Variant

ARP44286_T100-FITC

Size: 100 µL

Product Specifications

Gene Name

Sialidase 1 (lysosomal sialidase)

Gene Aliases

NEU, NANH, SIAL1

Gene ID

4758

Swiss Prot

Q99519

Accession Number

NP_000425

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human NEU1

Target

NEU1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in NEU1 gene can lead to sialidosis.The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein') . Mutations in this gene can lead to sialidosis.

Partner Proteins

FBXO6; JUNB; LIG4; KCNA4; KCNA2; UBC; HDAC5; CTSA; GLB1; EEF1A1; GALNS

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 79%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

45kDa

References & Citations

Hinek, A., (2006) J. Biol. Chem. 281 (6), 3698-3710

Shipping Conditions

Wet Ice

Protein Length

415

NCBI Gene Symbol

NEU1

NCBI GB Accession Number

NEU1

Host or Source

Rabbit

Protein Name

Sialidase-1

Nucleotide Accession Number

NM_000434

Peptide Sequence

VWSKDDGVSWSTPRNLSLDIGTEVFAPGPGSGIQKQREPRKGRLIVCGHG

Price

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