GHR Antibody - C-terminal region : Biotin (ARP44231_P050-Biotin)

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.

FBXW11; JAK2; GHR; GH1; BTRC; UBC; SKP1; SOCS2; STUB1; PTPRH; PTPRB; PTPN13; PTPN9; PTPN3; PTPN2; PTPN1; DUSP7; NCOA6; STAT5B; SOCS3; SOCS1; SGTA; CISH; GRB10; STAT5A; AP2A1; SHC1; TYK2; PTPN6; PTPN11; PRLR; PIK3R1; JAK1; IRS1; GH2; GRB2; STAT3; PLCG1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.