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ABCC1 Antibody - middle region : FITC (ARP43653_P050-FITC)

Product Specifications

Gene Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Gene Aliases

MRP, ABCC, GS-X, MRP1, ABC29, DFNA77

Gene ID

4363

Swiss Prot

P33527

Accession Number

NP_004987

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human ABCC1

Target

ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

Partner Proteins

UBC; ABCC1; CAV1; TRAF3; NPM1; AZGP1; STT3B; RAVER1; MCU; MRPL17; TMCO1; ATP6V1H; TMX2; TMOD2; NDUFAF3; FKBP8; PUF60; PGRMC2; FLOT1; PDCD6IP; ATP6V1F; EIF3C; PDHX; VDAC3; SURF1; STX4; SAFB; RPS7; NDUFB9; DBT; TMEM173; UNC93B1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 77%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 93%; Rat: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

171kDa

References & Citations

Nabekura, T., (2008) Biochem. Biophys. Res. Commun. 369 (2), 363-368

Shipping Conditions

Wet Ice

Protein Length

1531

NCBI Gene Symbol

ABCC1

NCBI GB Accession Number

ABCC1

Host or Source

Rabbit

Protein Name

Multidrug resistance-associated protein 1

Nucleotide Accession Number

NM_004996

Peptide Sequence

LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGA

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