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GCDH Antibody - N-terminal region : Biotin (ARP43568_P050-Biotin)

Product Specifications

Gene Name

Glutaryl-CoA dehydrogenase

Gene Aliases

GCD, ACAD5

Gene ID

2639

Swiss Prot

Q92947

Accession Number

NP_000150

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human GCDH

Target

GCDH belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO (2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits.Alternatively spliced transcript variants encoding different isoforms have been identified.The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO (2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.

Partner Proteins

UBC; FBXO6; ADRB2; RNF32; EXOC6; ECSIT; MAST1; CDC37; PSEN2; PSEN1; NOS3; APOE; A2M; UBD; MYC; GCDH

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

43kDa

References & Citations

Rao, K.S., (2006) Biochemistry 45 (51), 15853-15861

Shipping Conditions

Wet Ice

Protein Length

438

NCBI Gene Symbol

GCDH

NCBI GB Accession Number

GCDH

Host or Source

Rabbit

Protein Name

Glutaryl-CoA dehydrogenase, mitochondrial

Nucleotide Accession Number

NM_000159

Peptide Sequence

SLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRA

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