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STEAP3 Antibody - N-terminal region : Biotin (ARP43536_T100-Biotin)

Selected Variant

ARP43536_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

STEAP family member 3, metalloreductase

Gene Aliases

STMP3, TSAP6, pHyde, AHMIO2, dudlin-2, dudulin-2

Gene ID

55240

Swiss Prot

Q658P3

Accession Number

NP_001008410

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human STEAP3

Target

AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) and can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD (+) as acceptor (By similarity) . It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT

Partner Proteins

UBC; SETD7; BAD; TPT1; BNIP3L; PKMYT1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 79%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

54kDa

References & Citations

Amzallag, N., (2004) J. Biol. Chem. 279 (44), 46104-46112

Shipping Conditions

Wet Ice

Protein Length

488

NCBI Gene Symbol

STEAP3

NCBI GB Accession Number

STEAP3

Host or Source

Rabbit

Protein Name

Metalloreductase STEAP3

Nucleotide Accession Number

NM_001008410

Peptide Sequence

LVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHY

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