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AADAT Antibody - N-terminal region : Biotin (ARP43534_T100-Biotin)

Selected Variant

ARP43534_T100-Biotin

Size: 100 µL

Product Specifications

Gene Name

Aminoadipate aminotransferase

Gene Aliases

KAT2, KATII, KYAT2

Gene ID

51166

Swiss Prot

Q8N5Z0

Accession Number

NP_057312

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human AADAT

Target

AADAT is a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties.This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 79%; Rabbit: 100%; Rat: 85%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

47kDa

References & Citations

Goh, D.L., (2002) Mol. Genet. Metab. 76 (3), 172-180

Shipping Conditions

Wet Ice

Protein Length

425

NCBI Gene Symbol

AADAT

NCBI GB Accession Number

AADAT

Host or Source

Rabbit

Protein Name

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Nucleotide Accession Number

NM_016228

Peptide Sequence

AVITVENGKTIQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTI

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