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PCSK5 Antibody - middle region : Biotin (ARP43530_P050-Biotin)

Product Specifications

Gene Name

Proprotein convertase subtilisin/kexin type 5

Gene Aliases

PC5, PC6, PC6A, SPC6

Gene ID

5125

Swiss Prot

Q92824

Accession Number

NP_006191

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PCSK5

Target

PCSK5 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. PCSK5 mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively spliced transcripts are described for this gene but only one has its full length nature known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Partner Proteins

NOTCH2NL; KRTAP10-3; KRTAP10-8; KRTAP10-7; LCE3C; KRTAP4-12; NUFIP2; GLRX3; STK16; MEOX2; KRTAP5-9; env; Hoxa1; ATN1; UBC; CACNA1A; APPBP2; AMH; REN; PTPRM; PMCH; ITGA6

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

PCSK5 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

89kDa

References & Citations

Szumska, D., (2008) Genes Dev. 22 (11), 1465-1477

Shipping Conditions

Wet Ice

Protein Length

913

NCBI Gene Symbol

PCSK5

NCBI GB Accession Number

PCSK5

Host or Source

Rabbit

Protein Name

Proprotein convertase subtilisin/kexin type 5

Nucleotide Accession Number

NM_006200

Peptide Sequence

CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDIS

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