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STEAP3 Antibody - C-terminal region : FITC (ARP43515_P050-FITC)

Selected Variant

ARP43515_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

STEAP family member 3, metalloreductase

Gene Aliases

STMP3, TSAP6, pHyde, AHMIO2, dudlin-2, dudulin-2

Gene ID

55240

Swiss Prot

A8K6E3

Accession Number

NP_878919

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human STEAP3

Target

AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) and can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD (+) as acceptor (By similarity) . It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT.

Partner Proteins

UBC; SETD7; BAD; TPT1; BNIP3L; PKMYT1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

56kDa

References & Citations

Sendamarai, A.K., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (21), 7410-7415

Shipping Conditions

Wet Ice

Protein Length

498

NCBI Gene Symbol

STEAP3

NCBI GB Accession Number

STEAP3

Host or Source

Rabbit

Protein Name

Metalloreductase STEAP3

Nucleotide Accession Number

NM_182915

Peptide Sequence

VALVLSTLHTLTYGWTRAFEESRYKFYLPPTFTLTLLVPCVVILAKALFL

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