UBR1 Antibody - N-terminal region : Biotin (ARP43459_P050-Biotin)

UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CDC6; UBC; SHFM1; UBE2D1; CBX8; ZNF593; DNPH1; USP5; XPO1; PFAS; CSE1L; ATP6V1A; VCL; UCHL3; CUL2; RECQL4; TIRAP; DNAJB11; NUDT3; SPRY2; LAMTOR3; UBE2A; GSK3B; GADD45A; BCL2L1; UBE2Z; NSFL1C; UBXN1; UBXN7; FAF2; FAF1; FOS; HNRNPA1; NDUFA4L2; ARL15; BTBD2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.