Anti-Bonzo (NT2) Antibody

Rabbit Polyclonal Antibody specific to Bonzo (NT2)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

CXC-R6, CXCR-6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo, CD antigen CD186

Gene Name

CXCR6

Gene ID

10663

NCBI Gene ID

UniProt

O00574

Accession Number

NP_006555

Cellular Locus

Cell membrane; Multi-pass membrane protein.

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 11-25 at the N-terminus of human Bonzo. The sequence of this peptide differs from those of African green monkey and macaque by one or two amino acids, respectively.

Target Antigen

C-X-C chemokine receptor type 6

Target

Bonzo (NT2)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Infectious Disease

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Additionnal Information

Immunoblotting: use at 1:500 dilution. <br><br>Positive control: Tissue lysate of human spleen.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human Bonzo (40 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, and CCR2b,have previously been identified as HIV coreceptors. An orphan G protein- coupled receptor designated Bonzo was recently cloned and identified as a HIV- 1 and -2 and SIV coreceptor (also called STRL33 and TYMSTR). The messenger RNA for Bonzo is expressed in lymphoid tissues and activated peripheral blood lymphocytes.