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FBXO11 Antibody - middle region : Biotin (ARP43327_P050-Biotin)

Product Specifications

Gene Name

F-box protein 11

Gene Aliases

UBR6, VIT1, FBX11, PRMT9, IDDFBA, UG063H01

Gene ID

80204

Swiss Prot

Q6DF73

Accession Number

NP_079409

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human FBXO11

Target

FBXO11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for FBXO11.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Partner Proteins

SKP1; ERN1; DTL; CUL1; EED; UBC; NEDD8; COPS5; COPS6; ELAVL1; USP16; HDAC6; BCL6; RBX1; TP53

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB, CHIP

Purification

Affinity Purified

Sample Type

FBXO11 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

94kDa

References & Citations

Lee, M.J., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (1), 100-105

Shipping Conditions

Wet Ice

Protein Length

843

NCBI Gene Symbol

FBXO11

NCBI GB Accession Number

FBXO11

Host or Source

Rabbit

Protein Name

Fbxo11-prov protein EMBL AAH76869.1

Nucleotide Accession Number

NM_025133

Peptide Sequence

HDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQ

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