MARCH4 Antibody - N-terminal region : Biotin (ARP43280_P050-Biotin)
Product Specifications
Gene Name
Membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
Gene Aliases
MARCH4, RNF174, MARCH-IV
Gene ID
57574
Swiss Prot
Q9P2E8
Accession Number
NP_065865
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human MARCH4
Target
MARCH4 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Partner Proteins
UBE2H; UBE2D1; ULBP1; CD4
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Dog: 92%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 85%; Rabbit: 85%; Rat: 92%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
45kDa
References & Citations
Bartee, E., (2004) J. Virol. 78 (3), 1109-1120
Shipping Conditions
Wet Ice
Protein Length
410
NCBI Gene Symbol
44989
NCBI GB Accession Number
44989
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase MARCH4
Nucleotide Accession Number
NM_020814
Peptide Sequence
GLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQPPGLAANNTLPALGAG
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