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MARCH1 Antibody - N-terminal region : Biotin (ARP43239_P050-Biotin)

Product Specifications

Gene Name

Membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

Gene Aliases

MARCH1, RNF171, MARCH-I

Gene ID

55016

Swiss Prot

Q8TCQ1-2

Accession Number

NP_060393

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MARCH1

Target

MARCH1 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC, CD86 and FAS, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Partner Proteins

TNFRSF10A; UBE2H; UBE2D1; CDC34; TFRC; UBC; HLA-DRB1; HLA-DRA; PPP2R1B; PPP2R1A; CD86

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

31kDa

References & Citations

De (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (9), 3491-3496

Shipping Conditions

Wet Ice

Protein Length

272

NCBI Gene Symbol

44986

NCBI GB Accession Number

MARCH1

Host or Source

Rabbit

Protein Name

E3 ubiquitin-protein ligase MARCH1

Nucleotide Accession Number

NM_017923

Peptide Sequence

LQASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGT

Frequently Asked Questions

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