MARCH2 Antibody - C-terminal region : Biotin (ARP43220_P050-Biotin)

Product Specifications

Gene Name

Membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

Gene Aliases

MARCH2, RNF172, HSPC240, MARCH-II

Gene ID

51257

Swiss Prot

Q9P0N8

Accession Number

NP_057580

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human MARCH2

Target

MARCH2 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH2 may be involved in endosomal trafficking through interaction with STX6.

Partner Proteins

LDLRAD1; SYNE4; CCDC155; FATE1; UBE2H; UBE2D1; CDC34; GOPC; STX6; CFTR; ADRB2; ELAVL1; DLG1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Dog: 92%; Guinea Pig: 86%; Human: 100%; Mouse: 100%; Rabbit: 77%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.